PRKCA
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- activation of adenylate cyclase activity [ISS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- blood coagulation [TAS]
- desmosome assembly [IMP]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- histone H3-T6 phosphorylation [IDA]
- innate immune response [TAS]
- mRNA metabolic process [TAS]
- negative regulation of adenylate cyclase activity [ISS]
- negative regulation of glial cell apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cardiac muscle hypertrophy [ISS]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of dense core granule biogenesis [ISS]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of macrophage differentiation [ISS]
- positive regulation of mitotic cell cycle [IMP]
- protein phosphorylation [IDA]
- regulation of insulin secretion [TAS]
- regulation of platelet aggregation [IDA]
- regulation of rhodopsin mediated signaling pathway [TAS]
- response to interleukin-1 [IMP]
- rhodopsin mediated signaling pathway [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PICK1
Gene Ontology Biological Process
- ATP catabolic process [ISO, ISS]
- cellular response to decreased oxygen levels [IMP]
- cellular response to glucose starvation [IMP]
- dendritic spine maintenance [IMP]
- dendritic spine organization [IDA]
- dopamine transport [NAS]
- glial cell development [IMP]
- long term synaptic depression [IDA]
- monoamine transport [ISO, ISS]
- negative regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- negative regulation of cell death [IDA]
- negative regulation of gene expression [IMP]
- positive regulation of receptor internalization [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISO, ISS]
- protein phosphorylation [IDA]
- protein targeting [ISO]
- receptor clustering [IMP, ISO, ISS]
Gene Ontology Molecular Function- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
- ATPase activity [ISO, ISS]
- Arp2/3 complex binding [IDA]
- G-protein coupled glutamate receptor binding [TAS]
- G-protein coupled receptor binding [IPI, TAS]
- GTPase binding [TAS]
- actin filament binding [IDA]
- enzyme binding [ISO]
- ephrin receptor binding [TAS]
- identical protein binding [IDA]
- protein C-terminus binding [IPI, ISO, ISS]
- protein binding [IPI]
- protein domain specific binding [IMP]
- protein kinase C binding [IDA, ISO, ISS]
- receptor binding [IPI, ISO, ISS]
- receptor tyrosine kinase binding [TAS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO, ISS]
- cytoplasm [ISO, ISS]
- dendrite [IDA]
- mitochondrion [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [ISO]
- perinuclear region of cytoplasm [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- postsynaptic density [IDA]
- presynaptic membrane [ISO, ISS]
- protein complex [IDA]
- synapse [IDA, ISO, ISS]
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1.
TIS21 is induced transiently by PMA and a number of extracellular stimuli. Yeast two-hybrid screening has identified three TIS21 interacting clones from a rat cDNA library [Lin, Gary, Yang, Clarke and Herschman (1996) J. Biol. Chem 271, 15034-15044]. The amino acid sequence deduced from clone 5A shows 96.9% identity with the murine PICK1, a protein kinase Calpha (PKCalpha)-binding protein postulated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID