PAG1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CSK
Gene Ontology Biological Process
- adherens junction organization [IEP]
- brain development [IEP]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [IDA]
- innate immune response [IBA]
- morphogenesis of an epithelium [IBA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of Golgi to plasma membrane protein transport [ISO]
- negative regulation of bone resorption [IDA]
- negative regulation of cell proliferation [IDA, ISO]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of kinase activity [IDA]
- negative regulation of low-density lipoprotein particle clearance [IDA]
- negative regulation of phagocytosis [IDA]
- oligodendrocyte differentiation [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- positive regulation of MAP kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases.
The Src family of protein tyrosine kinases (Src-PTKs) is important in the regulation of growth and differentiation of eukaryotic cells. The activity of Src-PTKs in cells of different types is negatively controlled by Csk, which specifically phosphorylates a conserved regulatory tyrosine residue at the carboxy-terminal tail of the Src-PTKs. Csk is mainly cytoplasmic and Src-PTKs are predominantly membrane-associated. This raises ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CSK PAG1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID