BAIT
ACVR2A
ACTRII, ACVR2
activin A receptor, type IIA
GO Process (10)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, TAS]
- activin receptor signaling pathway [IDA]
- cellular response to BMP stimulus [IMP]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DAXX
BING2, DAP6, EAP1, DADB-159G18.9
death-domain associated protein
GO Process (12)
GO Function (14)
GO Component (5)
Gene Ontology Biological Process
- activation of JUN kinase activity [TAS]
- androgen receptor signaling pathway [IDA]
- apoptotic process [TAS]
- chromatin remodeling [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- nucleosome assembly [IDA]
- positive regulation of neuron death [IGI]
- positive regulation of protein kinase activity [IGI]
- positive regulation of protein phosphorylation [IGI]
- regulation of protein ubiquitination [IDA]
- regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- androgen receptor binding [IPI]
- enzyme binding [IPI]
- heat shock protein binding [TAS]
- histone binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activator activity [IGI]
- protein kinase binding [IPI]
- receptor signaling protein activity [TAS]
- transcription corepressor activity [IDA]
- transcription factor binding [IDA]
- ubiquitin protein ligase binding [IPI]
- androgen receptor binding [IPI]
- enzyme binding [IPI]
- heat shock protein binding [TAS]
- histone binding [IDA]
- p53 binding [IPI]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activator activity [IGI]
- protein kinase binding [IPI]
- receptor signaling protein activity [TAS]
- transcription corepressor activity [IDA]
- transcription factor binding [IDA]
- ubiquitin protein ligase binding [IPI]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.
Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that has a principal role in growth control through both its cytostatic effect on many different epithelial cell types and its ability to induce programmed cell death in a variety of other cell types. Here we have used a screen for proteins that interact physically with the cytoplasmic domain of the ... [more]
Nat. Cell Biol. Aug. 01, 2001; 3(8);708-14 [Pubmed: 11483955]
Throughput
- Low Throughput
Additional Notes
- Figure 1
Curated By
- BioGRID