CACYBP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
S100B
Gene Ontology Biological Process
- cellular calcium ion homeostasis [NAS]
- energy reserve metabolic process [NAS]
- learning or memory [IMP]
- memory [IMP]
- negative regulation of skeletal muscle cell differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- regulation of cell shape [ISO]
- regulation of cytokine biosynthetic process [NAS]
- regulation of long-term neuronal synaptic plasticity [NAS]
- regulation of neuronal synaptic plasticity [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family.
Recently, a human ortholog of mouse calcyclin (S100A6)-binding protein (CacyBP) called SIP (Siah-1-interacting protein) was shown to be a component of a novel ubiquitinylation pathway regulating beta-catenin degradation (Matsuzawa, S., and Reed, J. C. (2001) Mol. Cell 7, 915-926). In murine brain, CacyBP/SIP is expressed at a high level, but S100A6 is expressed at a very low level. Consequently we ... [more]
Throughput
- Low Throughput
Additional Notes
- source of proteins not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| S100B CACYBP | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.7155 | BioGRID | 2667482 |
Curated By
- BioGRID