An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-Î² hydroxysteroid dehydrogenase type 10.

Bertolin G, Jacoupy M, Traver S, Ferrando-Miguel R, Saint Georges T, Grenier K, Ardila-Osorio H, Muriel MP, Takahashi H, Lees AJ, Gautier C, Guedin D, Coge F, Fon EA, Brice A, Corti O

Mutations of the PARK2 and PINK1 genes, encoding the cytosolic E3 ubiquitin-protein ligase Parkin and the mitochondrial serine/threonine kinase PINK1, respectively, cause autosomal recessive early-onset Parkinson's disease (PD). Parkin and PINK1 cooperate in a biochemical mitochondrial quality control pathway regulating mitochondrial morphology, dynamics and clearance. This study identifies the multifunctional PD-related mitochondrial matrix enzyme 17-Î² hydroxysteroid dehydrogenase type 10 (HSD17B10) ... [more]

Cell Death Differ. Jan. 16, 2015; 0(0); [Pubmed: 25591737]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
HSD17B10 TOMM40	Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.	Wan C (2015)	High	0.0879	BioGRID	1273455

Curated By

BioGRID

Interaction Summary

TOMM40

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein transmembrane transporter activity [ISS, TAS]

Gene Ontology Cellular Component

HSD17B10