BAIT
MAGEA1
CT1.1, MAGE1
melanoma antigen family A, 1 (directs expression of antigen MZ2-E)
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MDM4
HDMX, MDMX, MRP1, RP11-430C7.1
MDM4, p53 regulator
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IEP]
- G0 to G1 transition [IEP]
- cell proliferation [IEP]
- cellular response to hypoxia [IEP]
- negative regulation of cell proliferation [TAS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- protein complex assembly [IDA]
- protein stabilization [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA, NAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex.
The MAGE (Melanoma-associated antigen) protein family members are structurally related to each other by a MAGE-homology domain comprised of 2 winged helix motifs WH/A and WH/B. This family specifically evolved in placental mammals although single homologs designated NSE3 (non-SMC element) exist in most eukaryotes. NSE3, together with its partner proteins NSE1 and NSE4 form a tight subcomplex of the structural ... [more]
Cell Cycle Jan. 16, 2015; 14(6);920-30 [Pubmed: 25590999]
Throughput
- Low Throughput
Curated By
- BioGRID