DAPK1
Gene Ontology Biological Process
- apoptotic process [IGI, IMP, TAS]
- apoptotic signaling pathway [IMP]
- cellular response to interferon-gamma [IDA]
- intracellular signal transduction [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- protein autophosphorylation [IDA, TAS]
- protein phosphorylation [IDA, TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of apoptotic process [IBA, TAS]
- regulation of autophagy [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UNC5C
Gene Ontology Biological Process
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase.
Netrin-1 receptors UNC5H (UNC5H1-4) were originally proposed to mediate the chemorepulsive activity of netrin-1 during axonal guidance processes. However, UNC5H receptors were more recently described as dependence receptors and, as such, able to trigger apoptosis in the absence of netrin-1. They were also proposed as putative tumor suppressors. Here, we show that UNC5H2 physically interacts with the serine/threonine kinase death-associated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID