CDKN2A
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- Ras protein signal transduction [IEP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- apoptotic mitochondrial changes [IMP]
- cell cycle arrest [IDA, IMP]
- cellular senescence [IMP]
- mitotic cell cycle [TAS]
- negative regulation of B cell proliferation [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of cell-matrix adhesion [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of immature T cell proliferation in thymus [ISS]
- negative regulation of phosphorylation [IDA]
- negative regulation of protein kinase activity [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- negative regulation of ubiquitin-protein transferase activity [ISS]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of cellular senescence [IMP]
- positive regulation of macrophage apoptotic process [ISS]
- positive regulation of protein sumoylation [IMP]
- positive regulation of smooth muscle cell apoptotic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein K63-linked ubiquitination [IDA]
- protein destabilization [IDA]
- protein polyubiquitination [IDA]
- protein stabilization [IDA]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of apoptotic DNA fragmentation [IMP]
- regulation of protein export from nucleus [IMP]
- regulation of protein stability [ISS]
- replicative senescence [IMP]
- senescence-associated heterochromatin focus assembly [IMP]
- somatic stem cell division [ISS]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
- MDM2/MDM4 family protein binding [IPI]
- NF-kappaB binding [IDA]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- p53 binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein kinase binding [IPI]
- transcription factor binding [IPI]
- ubiquitin-protein transferase inhibitor activity [ISS]
Gene Ontology Cellular Component
ZBTB17
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation.
Although Myc-interacting zinc-finger protein-1 (Miz-1) is known to be a poxvirus and zinc-finger (POZ) transcription factor required for Myc transcriptional repression, additional regulatory function of Miz-1 is less well understood. Using a yeast two-hybrid screen, we identified human alternate reading frame (ARF) protein as a novel interaction partner of Miz-1. The zinc-finger domain of Miz-1 is involved in its binding ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ZBTB17 CDKN2A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CDKN2A ZBTB17 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID