DCC
Gene Ontology Biological Process
- anterior/posterior axon guidance [IMP]
- axon guidance [ISO]
- dorsal/ventral axon guidance [IMP]
- netrin-activated signaling pathway [ISO]
- neuron migration [IMP]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of neuron death [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- spinal cord ventral commissure morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RPL5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.
Extracellular signals regulate protein translation in many cell functions. A key advantage of control at the translational level is the opportunity to regulate protein synthesis within specific cellular subregions. However, little is known about mechanisms that may link extracellular cues to translation with spatial precision. Here, we show that a transmembrane receptor, DCC, forms a binding complex containing multiple translation ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID