PPP1CA
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- entrainment of circadian clock by photoperiod [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein dephosphorylation [IMP, ISS]
- regulation of circadian rhythm [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
- triglyceride catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HDAC6
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP]
- aggresome assembly [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to topologically incorrect protein [IMP]
- histone deacetylation [IDA, ISS]
- intracellular protein transport [IMP]
- lysosome localization [IMP]
- macroautophagy [IMP]
- misfolded or incompletely synthesized protein catabolic process [IMP]
- negative regulation of hydrogen peroxide metabolic process [IC]
- negative regulation of oxidoreductase activity [IC]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- peptidyl-lysine deacetylation [IMP]
- polyubiquitinated misfolded protein transport [IMP]
- positive regulation of chaperone-mediated protein complex assembly [IMP]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of hydrogen peroxide-mediated programmed cell death [IDA]
- positive regulation of receptor biosynthetic process [IMP]
- positive regulation of signal transduction [IMP]
- protein deacetylation [IMP]
- regulation of androgen receptor signaling pathway [TAS]
- regulation of gene expression, epigenetic [IMP]
- regulation of microtubule-based movement [IC]
- regulation of receptor activity [IMP]
- response to growth factor [IMP]
- response to misfolded protein [IMP]
- response to organic substance [IMP]
- response to toxic substance [IMP]
- tubulin deacetylation [IDA, ISS]
Gene Ontology Molecular Function- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
- Hsp90 protein binding [IDA]
- alpha-tubulin binding [IDA]
- beta-catenin binding [IPI]
- core promoter binding [IDA]
- dynein complex binding [IDA]
- enzyme binding [ISS]
- histone deacetylase activity [IDA]
- histone deacetylase binding [IPI]
- microtubule binding [IDA, ISS]
- polyubiquitin binding [IDA]
- protein binding [IPI]
- tau protein binding [IDA]
- tubulin deacetylase activity [IDA, ISS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- aggresome [IDA]
- axon [ISS]
- caveola [IDA]
- cell leading edge [IDA]
- cytoplasm [ISS]
- cytosol [ISS]
- dendrite [ISS]
- dynein complex [IDA]
- histone deacetylase complex [IDA]
- inclusion body [IDA]
- microtubule [IDA]
- microtubule associated complex [IDA]
- nucleoplasm [IDA]
- nucleus [ISS]
- perikaryon [ISS]
- perinuclear region of cytoplasm [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.
Despite advances in understanding the role of histone deacetylases (HDACs) in tumorigenesis, the mechanism by which HDAC inhibitors mediate antineoplastic effects remains elusive. Modifications of the histone code alone are not sufficient to account for the antitumor effect of HDAC inhibitors. The present study demonstrates a novel histone acetylation-independent mechanism by which HDAC inhibitors cause Akt dephosphorylation in U87MG glioblastoma ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HDAC6 PPP1CA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID