BAIT
CHEK2
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, RP11-436C9.1
checkpoint kinase 2
GO Process (17)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage checkpoint [TAS]
- DNA damage induced protein phosphorylation [IMP]
- G2/M transition of mitotic cell cycle [IMP]
- cellular protein catabolic process [IMP]
- cellular response to DNA damage stimulus [IMP, TAS]
- double-strand break repair [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- protein stabilization [IDA]
- regulation of protein catabolic process [IMP]
- regulation of transcription, DNA-templated [IDA]
- replicative senescence [NAS]
- signal transduction in response to DNA damage [IDA]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDH13
CDHH, P105
cadherin 13
GO Process (24)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- Rho protein signal transduction [IMP]
- adherens junction organization [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- endothelial cell migration [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- keratinocyte proliferation [IDA]
- lamellipodium assembly [IDA]
- localization within membrane [IMP]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell proliferation [IDA]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of endocytosis [IMP]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- sprouting angiogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of molecular links between core and candidate genes in breast cancer.
Despite the remarkable progress achieved in the identification of specific genes involved in breast cancer (BC), our understanding of their complex functioning is still limited. In this manuscript, we systematically explore the existence of direct physical interactions between the products of BC core and associated genes. Our aim is to generate a protein interaction network of BC-associated gene products and ... [more]
J. Mol. Biol. Mar. 27, 2015; 427(6);1436-50 [Pubmed: 25640309]
Throughput
- High Throughput
Curated By
- BioGRID