BAIT
TGFB1
CED, DPD1, LAP, TGFB, TGFbeta
transforming growth factor, beta 1
GO Process (102)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- ATP biosynthetic process [IDA]
- MAPK cascade [IMP]
- SMAD protein complex assembly [IDA]
- SMAD protein import into nucleus [IDA]
- SMAD protein signal transduction [IBA]
- active induction of host immune response by virus [TAS]
- blood coagulation [TAS]
- cell cycle arrest [IDA]
- cell-cell junction organization [IDA]
- cellular response to organic cyclic compound [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- chondrocyte differentiation [IDA]
- common-partner SMAD protein phosphorylation [IDA]
- connective tissue replacement involved in inflammatory response wound healing [TAS]
- epidermal growth factor receptor signaling pathway [IDA]
- evasion or tolerance of host defenses by virus [IDA]
- extracellular matrix assembly [IDA]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- hematopoietic progenitor cell differentiation [IDA]
- hyaluronan catabolic process [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymph node development [ISS]
- macrophage derived foam cell differentiation [IC]
- mitotic cell cycle checkpoint [IDA]
- modulation by virus of host morphology or physiology [TAS]
- negative regulation of DNA replication [IMP]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell-cell adhesion [IDA]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of extracellular matrix disassembly [IC]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of hyaluronan biosynthetic process [IDA]
- negative regulation of macrophage cytokine production [IDA]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- ossification involved in bone remodeling [IEP]
- pathway-restricted SMAD protein phosphorylation [IDA]
- phosphate-containing compound metabolic process [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NAD+ ADP-ribosyltransferase activity [IDA]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of bone mineralization [IEP]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of collagen biosynthetic process [IDA, IMP]
- positive regulation of epithelial to mesenchymal transition [IDA, NAS]
- positive regulation of extracellular matrix assembly [IC]
- positive regulation of fibroblast migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of interleukin-17 production [IDA]
- positive regulation of isotype switching to IgA isotypes [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein dephosphorylation [IDA]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of superoxide anion generation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription regulatory region DNA binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- positive regulation vascular endothelial growth factor production [TAS]
- protein export from nucleus [IDA]
- protein import into nucleus, translocation [IDA]
- protein kinase B signaling [IMP]
- protein phosphorylation [ISS]
- receptor catabolic process [IDA]
- regulation of DNA binding [ISS]
- regulation of apoptotic process [IBA]
- regulation of binding [ISS]
- regulation of blood vessel remodeling [IC]
- regulation of cell migration [TAS]
- regulation of miRNA metabolic process [IDA]
- regulation of protein import into nucleus [ISS]
- regulation of striated muscle tissue development [ISS]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to cholesterol [IDA]
- response to estradiol [IDA]
- response to progesterone [IDA]
- response to wounding [IEP]
- salivary gland morphogenesis [IEP]
- transforming growth factor beta receptor signaling pathway [IDA, TAS]
- viral life cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CCL5
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
chemokine (C-C motif) ligand 5
GO Process (62)
GO Function (14)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IMP]
- activation of phospholipase D activity [IDA]
- calcium ion transport [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular protein complex assembly [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemokine-mediated signaling pathway [IDA, TAS]
- chemotaxis [NAS]
- dendritic cell chemotaxis [TAS]
- eosinophil chemotaxis [IDA]
- exocytosis [IDA]
- inflammatory response [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [TAS]
- monocyte chemotaxis [IC]
- negative regulation by host of viral transcription [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of T cell apoptotic process [IDA]
- negative regulation of chemokine-mediated signaling pathway [IDA]
- negative regulation of viral genome replication [IDA]
- neutrophil activation [IDA]
- positive chemotaxis [IDA]
- positive regulation of JAK-STAT cascade [TAS]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of T cell chemotaxis [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of activation of JAK2 kinase activity [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-cell adhesion mediated by integrin [IDA]
- positive regulation of cellular biosynthetic process [IDA]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of innate immune response [TAS]
- positive regulation of macrophage chemotaxis [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of translational initiation [NAS]
- positive regulation of tyrosine phosphorylation of STAT protein [IDA]
- positive regulation of viral genome replication [TAS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of T cell activation [IDA]
- regulation of chronic inflammatory response [TAS]
- regulation of insulin secretion [IDA]
- regulation of neuron death [IDA]
- response to toxic substance [IDA]
- response to virus [TAS]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of molecular links between core and candidate genes in breast cancer.
Despite the remarkable progress achieved in the identification of specific genes involved in breast cancer (BC), our understanding of their complex functioning is still limited. In this manuscript, we systematically explore the existence of direct physical interactions between the products of BC core and associated genes. Our aim is to generate a protein interaction network of BC-associated gene products and ... [more]
J. Mol. Biol. Mar. 27, 2015; 427(6);1436-50 [Pubmed: 25640309]
Throughput
- High Throughput
Curated By
- BioGRID