BAIT
WT1
AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Wilms tumor 1
GO Process (47)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- RNA splicing [ISS]
- adrenal cortex formation [ISS]
- adrenal gland development [IGI]
- branching involved in ureteric bud morphogenesis [IGI]
- camera-type eye development [ISS]
- cardiac muscle cell fate commitment [ISS]
- cellular response to cAMP [IEP]
- cellular response to gonadotropin stimulus [IDA]
- diaphragm development [ISS]
- epithelial cell differentiation [ISS]
- germ cell development [ISS]
- glomerular basement membrane development [IMP]
- glomerular visceral epithelial cell differentiation [IBA, ISS]
- glomerulus development [IGI]
- gonad development [ISS]
- heart development [IGI]
- kidney development [IGI]
- male genitalia development [ISS]
- male gonad development [IEP]
- mesenchymal to epithelial transition [ISS]
- metanephric S-shaped body morphogenesis [IGI]
- metanephric epithelium development [IEP]
- metanephric mesenchyme development [ISS]
- negative regulation of apoptotic process [IGI]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of female gonad development [ISS]
- negative regulation of metanephric glomerular mesangial cell proliferation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of heart growth [ISS]
- positive regulation of male gonad development [ISS]
- positive regulation of metanephric ureteric bud development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- posterior mesonephric tubule development [ISS]
- regulation of organ formation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [ISS, NAS]
- sex determination [IDA]
- thorax and anterior abdomen determination [ISS]
- tissue development [ISS]
- ureteric bud development [ISS]
- vasculogenesis [ISS]
- visceral serous pericardium development [IGI]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
- C2H2 zinc finger domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- cytoplasm [IBA, ISS]
- nuclear speck [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
CCL5
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
chemokine (C-C motif) ligand 5
GO Process (62)
GO Function (14)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IMP]
- activation of phospholipase D activity [IDA]
- calcium ion transport [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular protein complex assembly [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemokine-mediated signaling pathway [IDA, TAS]
- chemotaxis [NAS]
- dendritic cell chemotaxis [TAS]
- eosinophil chemotaxis [IDA]
- exocytosis [IDA]
- inflammatory response [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [TAS]
- monocyte chemotaxis [IC]
- negative regulation by host of viral transcription [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of T cell apoptotic process [IDA]
- negative regulation of chemokine-mediated signaling pathway [IDA]
- negative regulation of viral genome replication [IDA]
- neutrophil activation [IDA]
- positive chemotaxis [IDA]
- positive regulation of JAK-STAT cascade [TAS]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of T cell chemotaxis [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of activation of JAK2 kinase activity [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-cell adhesion mediated by integrin [IDA]
- positive regulation of cellular biosynthetic process [IDA]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of innate immune response [TAS]
- positive regulation of macrophage chemotaxis [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of translational initiation [NAS]
- positive regulation of tyrosine phosphorylation of STAT protein [IDA]
- positive regulation of viral genome replication [TAS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of T cell activation [IDA]
- regulation of chronic inflammatory response [TAS]
- regulation of insulin secretion [IDA]
- regulation of neuron death [IDA]
- response to toxic substance [IDA]
- response to virus [TAS]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of molecular links between core and candidate genes in breast cancer.
Despite the remarkable progress achieved in the identification of specific genes involved in breast cancer (BC), our understanding of their complex functioning is still limited. In this manuscript, we systematically explore the existence of direct physical interactions between the products of BC core and associated genes. Our aim is to generate a protein interaction network of BC-associated gene products and ... [more]
J. Mol. Biol. Mar. 27, 2015; 427(6);1436-50 [Pubmed: 25640309]
Throughput
- High Throughput
Curated By
- BioGRID