BAIT
CHEK2
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1, RP11-436C9.1
checkpoint kinase 2
GO Process (17)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- DNA damage checkpoint [TAS]
- DNA damage induced protein phosphorylation [IMP]
- G2/M transition of mitotic cell cycle [IMP]
- cellular protein catabolic process [IMP]
- cellular response to DNA damage stimulus [IMP, TAS]
- double-strand break repair [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- protein stabilization [IDA]
- regulation of protein catabolic process [IMP]
- regulation of transcription, DNA-templated [IDA]
- replicative senescence [NAS]
- signal transduction in response to DNA damage [IDA]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
- spindle assembly involved in mitosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A6
2, 3, AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y, RP11-261P4.6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- ADP transport [NAS]
- ATP transport [NAS]
- active induction of host immune response by virus [TAS]
- cellular protein metabolic process [TAS]
- energy reserve metabolic process [TAS]
- modulation by virus of host morphology or physiology [TAS]
- protein targeting to mitochondrion [TAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Systematic identification of molecular links between core and candidate genes in breast cancer.
Despite the remarkable progress achieved in the identification of specific genes involved in breast cancer (BC), our understanding of their complex functioning is still limited. In this manuscript, we systematically explore the existence of direct physical interactions between the products of BC core and associated genes. Our aim is to generate a protein interaction network of BC-associated gene products and ... [more]
J. Mol. Biol. Mar. 27, 2015; 427(6);1436-50 [Pubmed: 25640309]
Throughput
- High Throughput
Curated By
- BioGRID