AMOT
Gene Ontology Biological Process
- actin cytoskeleton organization [IMP]
- blood vessel endothelial cell migration [IMP]
- blood vessel morphogenesis [IMP]
- cell migration involved in gastrulation [IMP]
- cellular protein localization [IMP, ISO]
- chemotaxis [IMP]
- establishment of cell polarity involved in ameboidal cell migration [IMP]
- gastrulation with mouth forming second [IMP]
- hippo signaling [ISO]
- in utero embryonic development [IMP]
- negative regulation of GTPase activity [IMP]
- negative regulation of angiogenesis [ISO]
- negative regulation of vascular permeability [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of embryonic development [IMP]
- regulation of cell migration [ISO]
- regulation of small GTPase mediated signal transduction [IMP]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
INADL
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
Controlled regulation of Rho GTPase activity is an essential component mediating growth factor-stimulated migration. We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial migration during embryogenesis. However, the signaling pathways by which Amot controls directional migration are not known. Here we have used peptide pull-down and yeast 2-hybrid (Y2H) ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AMOT INADL | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | 1425747 | |
| INADL AMOT | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID