BAIT

PLEKHG5

BC023181, Syx, RP23-284C20.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Mus musculus
PREY

LIN7C

9130007B12Rik, AI303698, AU019331, AW125731, D2Ertd520e, LIN-7-C, LIN-7C, MALS-3, Veli3, RP23-207C2.1
lin-7 homolog C (C. elegans)
Mus musculus

Protein-peptide

An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.

Publication

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.

Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L

Controlled regulation of Rho GTPase activity is an essential component mediating growth factor-stimulated migration. We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial migration during embryogenesis. However, the signaling pathways by which Amot controls directional migration are not known. Here we have used peptide pull-down and yeast 2-hybrid (Y2H) ... [more]

Blood Jan. 01, 2009; 113(1);244-53 [Pubmed: 18824598]

Throughput

  • Low Throughput

Additional Notes

  • Syx peptides were used in the experiment.

Curated By

  • BioGRID