BAIT
PLEKHG5
BC023181, Syx, RP23-284C20.1
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
GO Process (5)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MYO1C
C80397, MMIb, MYO1E, NMI, mm1beta, myr2, RP23-136K12.2
myosin IC
GO Process (9)
GO Function (8)
GO Component (15)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell migration by vascular endothelial growth factor signaling pathway [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of vascular endothelial growth factor signaling pathway [ISO]
- protein targeting [ISO]
- protein targeting to membrane [ISO]
- regulation of tight junction assembly [ISO]
- transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basal plasma membrane [ISO]
- brush border [IDA]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- lateral plasma membrane [ISO]
- membrane [ISO, TAS]
- membrane raft [ISO]
- microvillus [ISO]
- mitochondrion [ISO]
- myosin I complex [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- plasma membrane [ISO]
- stereocilium [IDA]
Mus musculus
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
Controlled regulation of Rho GTPase activity is an essential component mediating growth factor-stimulated migration. We have previously shown that angiomotin (Amot), a membrane-associated scaffold protein, plays a critical role during vascular patterning and endothelial migration during embryogenesis. However, the signaling pathways by which Amot controls directional migration are not known. Here we have used peptide pull-down and yeast 2-hybrid (Y2H) ... [more]
Blood Jan. 01, 2009; 113(1);244-53 [Pubmed: 18824598]
Throughput
- Low Throughput
Additional Notes
- Syx peptides were used in the experiment.
Curated By
- BioGRID