BAIT

EWSR1

EWS, bK984G1.4, AC002059.7
EWS RNA-binding protein 1
GO Process (0)
GO Function (4)
GO Component (3)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

KCTD12

C13orf2, PFET1, PFETIN
potassium channel tetramerization domain containing 12
UPS Project
GO Process (0)
GO Function (1)
GO Component (1)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

Elzi DJ, Song M, Hakala K, Weintraub ST, Shiio Y

Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly Fli-1. EWS-Fli-1 fusion accounts for 85% of cases. The growth and survival of Ewing sarcoma cells are critically dependent on EWS-Fli-1. A large body of evidence has established that EWS-Fli-1 functions ... [more]

J. Proteome Res. Aug. 01, 2014; 13(8);3783-91 [Pubmed: 24999758]

Throughput

  • High Throughput

Additional Notes

  • BioID

Curated By

  • BioGRID