BAIT
HERC2
D15F37S1, MRT38, SHEP1, jdf2, p528
HECT and RLD domain containing E3 ubiquitin protein ligase 2
GO Process (6)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
AKAP9
AKAP-9, AKAP350, AKAP450, CG-NAP, HYPERION, LQT11, MU-RMS-40.16A, PPP1R45, PRKA9, YOTIAO
A kinase (PRKA) anchor protein 9
GO Process (10)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- cellular response to cAMP [IMP]
- mitotic cell cycle [TAS]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of potassium ion transmembrane transporter activity [IMP]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of membrane repolarization [IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- synaptic transmission [TAS]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.
HERC2 is a large E3 ubiquitin ligase with multiple structural domains that has been implicated in an array of cellular processes. Mutations in HERC2 are linked to developmental delays and impairment caused by nervous system dysfunction, such as Angelman Syndrome and autism-spectrum disorders. However, HERC2 cellular activity and regulation remain poorly understood. We used a broad proteomic approach to survey ... [more]
J. Proteome Res. Feb. 06, 2015; 14(2);953-66 [Pubmed: 25476789]
Throughput
- High Throughput
Curated By
- BioGRID