BAIT

SOD2

superoxide dismutase SOD2, L000001979, YHR008C
Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity; phosphorylated
Saccharomyces cerevisiae (S288c)
PREY

AIM32

YML050W
Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss
GO Process (0)
GO Function (0)
GO Component (0)
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth.

Laleve A, Vallieres C, Golinelli-Cohen MP, Bouton C, Song Z, Pawlik G, Tindall SM, Avery SV, Clain J, Meunier B

Malaria is a major health burden in tropical and subtropical countries. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. Yet its mechanism of action is still poorly understood. In this study, we used the yeast Saccharomyces cerevisiae model to help uncover the mode of ... [more]

Redox Biol Apr. 01, 2016; 7(0);21-9 [Pubmed: 26629948]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • AIM32 overexpression rescues primaquine sensitivity of sod2 mutant
  • Figure 2

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
AIM32 SOD2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.439BioGRID
2158151
SOD2 AIM32
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.549BioGRID
2125645
AIM32 SOD2
Reconstituted Complex
Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Low-BioGRID
-

Curated By

  • BioGRID