BAIT

CEP170

FAM68A, KAB, KIAA0470

centrosomal protein 170kDa

GO Process (0)

GO Function (1)

GO Component (4)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

centriole [IDA]

centrosome [IDA]

cytoplasm [IDA]

nuclear membrane [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

ARRB2

ARB2, ARR2, BARR2

arrestin, beta 2

GO Process (18)

GO Function (7)

GO Component (6)

Gene Ontology Biological Process

G-protein coupled receptor internalization [IDA, IMP]

Notch signaling pathway [TAS]

blood coagulation [TAS]

cell chemotaxis [IMP]

desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IMP]

negative regulation of NF-kappaB transcription factor activity [IDA]

negative regulation of natural killer cell mediated cytotoxicity [IMP]

negative regulation of protein ubiquitination [IDA]

platelet activation [TAS]

positive regulation of ERK1 and ERK2 cascade [IDA, IMP]

positive regulation of protein ubiquitination [IGI]

positive regulation of receptor internalization [IMP]

proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]

protein ubiquitination [IMP]

receptor internalization [IDA]

regulation of androgen receptor signaling pathway [IDA]

transcription from RNA polymerase II promoter [IDA]

transforming growth factor beta receptor signaling pathway [IDA]

Gene Ontology Molecular Function

G-protein coupled receptor binding [IPI]
angiotensin receptor binding [IPI]
enzyme binding [IPI]
protein binding [IPI]
protein complex scaffold [IDA]
receptor binding [IPI]
ubiquitin protein ligase binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

cytoplasmic vesicle [IDA]

endocytic vesicle [IDA]

plasma membrane [IDA, TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.

Gupta GD, Coyaud E, Goncalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, Hildebrandt F, Moffat J, Gingras AC, Raught B, Pelletier L

The centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of criticalÂ cellular functions. Here, we use proximity-dependent biotinylation (BioID) to map the centrosome-cilium interface; with 58 bait proteins we generate a protein topology network comprising >7,000 interactions. Analysis of interaction profiles coupled withÂ high resolution phenotypic profiling implicates a ... [more]

Cell Dec. 03, 2015; 163(6);1484-99 [Pubmed: 26638075]

Throughput

High Throughput

Additional Notes

BioID

Curated By

BioGRID