BAIT
DCTN1
DAP-150, DP-150, P135
dynactin 1
GO Process (9)
GO Function (1)
GO Component (8)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- mitotic cell cycle [TAS]
- mitotic nuclear division [NAS]
- nervous system development [NAS]
- retrograde transport, endosome to Golgi [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NACA
NACA1, skNAC, HSD48
nascent polypeptide-associated complex alpha subunit
GO Process (10)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cardiac ventricle development [ISS]
- heart trabecula morphogenesis [ISS]
- negative regulation of striated muscle cell apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter involved in heart development [ISS]
- positive regulation of cell proliferation involved in heart morphogenesis [ISS]
- positive regulation of skeletal muscle tissue growth [ISS]
- positive regulation of transcription from RNA polymerase II promoter involved in heart development [ISS]
- regulation of skeletal muscle fiber development [ISS]
- skeletal muscle tissue regeneration [ISS]
- translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface.
The centrosome is the primary microtubule organizing center of the cells and templates the formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use proximity-dependent biotinylation (BioID) to map the centrosome-cilium interface; with 58 bait proteins we generate a protein topology network comprising >7,000 interactions. Analysis of interaction profiles coupled with high resolution phenotypic profiling implicates a ... [more]
Cell Dec. 03, 2015; 163(6);1484-99 [Pubmed: 26638075]
Throughput
- High Throughput
Additional Notes
- BioID
Curated By
- BioGRID