EOMES
Gene Ontology Biological Process
- CD8-positive, alpha-beta T cell differentiation involved in immune response [IDA, ISO]
- blastocyst development [IMP]
- brain development [ISO]
- cardioblast differentiation [IMP]
- cell differentiation [IMP]
- cell differentiation involved in embryonic placenta development [IMP]
- cerebral cortex neuron differentiation [IDA]
- cerebral cortex regionalization [IMP]
- endoderm formation [IMP]
- endodermal cell fate specification [IMP]
- interferon-gamma production [IDA]
- mesoderm formation [IMP]
- mesodermal to mesenchymal transition involved in gastrulation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- olfactory bulb development [IMP]
- positive regulation of cell differentiation [IDA, IGI]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of gene expression [IMP]
- regulation of neurogenesis [IMP]
- regulation of neuron differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- skeletal muscle cell differentiation [IMP]
- stem cell maintenance [IMP]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IDA, IGI]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
ELF5
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.
Elf5 is a transcription factor with pivotal roles in the trophoblast compartment, where it reinforces a trophoblast stem cell (TSC)-specific transcriptional circuit. However, Elf5 is also present in differentiating trophoblast cells that have ceased to express other TSC genes such as Cdx2 and Eomes. In the present study, we aimed to elucidate the context-dependent role of Elf5 at the interface ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ELF5 EOMES | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| ELF5 EOMES | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID