BAIT
OTX2
E130306E05Rik
orthodenticle homolog 2
GO Process (28)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- anatomical structure development [IGI]
- anterior/posterior pattern specification [IGI, IMP]
- axon guidance [ISO]
- cell differentiation [IMP]
- cell fate commitment [IMP]
- cell fate specification [IMP]
- central nervous system development [IMP]
- diencephalon morphogenesis [IGI]
- dorsal/ventral pattern formation [IMP]
- endoderm development [IGI]
- eye photoreceptor cell fate commitment [IMP]
- forebrain development [IGI, IMP]
- inner ear morphogenesis [IGI]
- metencephalon development [IGI]
- midbrain development [IGI, IMP]
- neuron differentiation [IMP]
- neuron fate commitment [IMP]
- neuron fate determination [IMP]
- organ morphogenesis [IMP]
- positive regulation of embryonic development [IMP]
- positive regulation of gastrulation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IMP]
- primitive streak formation [IMP]
- protein complex assembly [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- somite rostral/caudal axis specification [IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
Gene Ontology Cellular Component
- cytoplasm [IDA]
- growth cone [ISO]
- nucleus [IC, IDA]
- protein complex [ISO]
Mus musculus
PREY
SIX6
Optx2, Six9
sine oculis-related homeobox 6
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comprehensive interactome of Otx2 in the adult mouse neural retina.
The Otx2 homeodomain transcription factor exerts multiple functions in specific developmental contexts, probably through the regulation of different sets of genes. Protein partners of Otx2 have been shown to modulate its activity. Therefore, the Otx2 interactome may play a key role in selecting a precise target-gene repertoire, hence determining its function in a specific tissue. To address the nature of ... [more]
Genesis Nov. 01, 2015; 53(11);685-94 [Pubmed: 26426291]
Throughput
- Low Throughput
Curated By
- BioGRID