BAIT
XPO1
CRM1, emb, exp1
exportin 1
GO Process (12)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRKD2
PKD2, nPKC-D2, HSPC187
protein kinase D2
GO Process (31)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- cell death [IMP]
- cellular response to vascular endothelial growth factor stimulus [IGI, IMP]
- endothelial tube morphogenesis [TAS]
- intracellular signal transduction [IMP]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IGI]
- positive regulation of DNA biosynthetic process [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of T cell receptor signaling pathway [ISS]
- positive regulation of angiogenesis [IGI, IMP]
- positive regulation of blood vessel endothelial cell migration [IGI, IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of endothelial cell chemotaxis [IMP]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IGI, IMP]
- positive regulation of fibroblast growth factor receptor signaling pathway [IMP]
- positive regulation of histone deacetylase activity [IGI]
- positive regulation of interleukin-2 production [ISS]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IMP]
- protein autophosphorylation [IDA, TAS]
- protein kinase D signaling [IGI]
- protein phosphorylation [NAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from the yeast S. cerevisiae, ≈ 1000 from Xenopus oocytes and >1050 from human cells. In addition, we quantified the partitioning of ≈5000 unique ... [more]
Elife Dec. 17, 2015; 4(0); [Pubmed: 26673895]
Throughput
- High Throughput
Additional Notes
- Cargo A
- Intreaction in the presence of RanGTP
Curated By
- BioGRID