BAIT
XPO1
CRM1, emb, exp1
exportin 1
GO Process (12)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP47
TRFP
ubiquitin specific peptidase 47
GO Process (12)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- base-excision repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to UV [ISS]
- monoubiquitinated protein deubiquitination [IDA]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell growth [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- regulation of proteasomal protein catabolic process [IBA]
- response to drug [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from the yeast S. cerevisiae, ≈ 1000 from Xenopus oocytes and >1050 from human cells. In addition, we quantified the partitioning of ≈5000 unique ... [more]
Elife Dec. 17, 2015; 4(0); [Pubmed: 26673895]
Throughput
- High Throughput
Additional Notes
- Cargo B
- Intreaction in the presence of RanGTP
Curated By
- BioGRID