BAIT
XPO1
CRM1, emb, exp1
exportin 1
GO Process (12)
GO Function (3)
GO Component (11)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- gene expression [TAS]
- intracellular transport of virus [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- protein export from nucleus [IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit export from nucleus [IMP]
- transforming growth factor beta receptor signaling pathway [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ITGB1BP1
ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B
integrin beta 1 binding protein 1
GO Process (34)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- activation of protein kinase B activity [IDA]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IDA]
- cell migration [TAS]
- cell-matrix adhesion [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- integrin activation [ISS]
- integrin-mediated signaling pathway [IDA]
- intracellular signal transduction [TAS]
- myoblast migration [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of cell adhesion involved in substrate-bound cell migration [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast migration [ISS]
- negative regulation of focal adhesion assembly [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein targeting to membrane [IDA]
- negative regulation of substrate adhesion-dependent cell spreading [IDA]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein targeting to membrane [ISS]
- positive regulation of stress fiber assembly [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein transport [IDA]
- receptor clustering [ISS]
- regulation of Cdc42 GTPase activity [IDA]
- regulation of blood vessel size [IDA]
- regulation of cell adhesion mediated by integrin [ISS]
- regulation of integrin-mediated signaling pathway [ISS]
- tube formation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
CRM1 is a highly conserved, RanGTPase-driven exportin that caries proteins and RNPs from the nucleus to the cytoplasm. We now explored the cargo-spectrum of CRM1 in depth and identified surprisingly large numbers, namely >700 export substrates from the yeast S. cerevisiae, ≈ 1000 from Xenopus oocytes and >1050 from human cells. In addition, we quantified the partitioning of ≈5000 unique ... [more]
Elife Dec. 17, 2015; 4(0); [Pubmed: 26673895]
Throughput
- High Throughput
Additional Notes
- Intreaction in the presence of RanGTP
- Low Abundant Cargo
Curated By
- BioGRID