PRI1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RFA2
Gene Ontology Biological Process
- DNA repair [IMP]
- DNA replication [IMP]
- DNA topological change [IDA]
- DNA unwinding involved in DNA replication [IDA]
- double-strand break repair via homologous recombination [IGI]
- establishment of protein localization [IMP]
- heteroduplex formation [IDA]
- mitotic recombination [IPI]
- nucleotide-excision repair [IDA, IMP]
- protein ubiquitination [IPI]
- reciprocal meiotic recombination [IPI]
- telomere maintenance via recombination [IPI]
- telomere maintenance via telomerase [IMP]
- telomere maintenance via telomere lengthening [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Association of RPA with chromosomal replication origins requires an Mcm protein, and is regulated by Rad53, and cyclin- and Dbf4-dependent kinases.
Eukaryotic cells use multiple replication origins to replicate their large genomes. Some origins fire early during S phase whereas others fire late. In Saccharomyces cerevisiae, initiator sequences (ARSs) are bound by the origin recognition complex (ORC). Cdc6p synthesized at the end of mitosis joins ORC and facilitates recruitment of Mcm proteins, which renders origins competent to fire. However, origins fire ... [more]
Throughput
- Low Throughput
Additional Notes
- Association of Pri1 on ARS dependent on Rfa2 and Cdc17
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RFA2 PRI1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.6853 | BioGRID | 1950455 |
Curated By
- BioGRID