BAIT
VAPA
VAP-33, VAP-A, VAP33, hVAP-33
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
GO Process (16)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- COPII-coated vesicle budding [IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- cell death [IMP]
- endoplasmic reticulum organization [IMP]
- membrane fusion [TAS]
- negative regulation by host of viral genome replication [IDA]
- neuron projection development [IMP]
- positive regulation by host of viral genome replication [IDA]
- positive regulation by host of viral release from host cell [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- protein folding in endoplasmic reticulum [IMP]
- protein localization to endoplasmic reticulum [IMP]
- signal transduction [IMP]
- small molecule metabolic process [TAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TAP1
ABC17, ABCB2, APT1, D6S114E, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N, DAAP-57C1.5
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
GO Process (8)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of endogenous peptide antigen via MHC class I [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cytosol to ER transport [IMP]
- intracellular transport of viral protein in host cell [IMP]
- peptide transport [IMP]
- transmembrane transport [IBA]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class Ib protein binding [IPI]
- TAP1 binding [ISS]
- TAP2 binding [IPI]
- peptide antigen binding [NAS]
- peptide transporter activity [IGI, IMP]
- protein binding [IPI]
- protein homodimerization activity [ISS]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity, coupled to transmembrane movement of substances [IBA]
- MHC class Ib protein binding [IPI]
- TAP1 binding [ISS]
- TAP2 binding [IPI]
- peptide antigen binding [NAS]
- peptide transporter activity [IGI, IMP]
- protein binding [IPI]
- protein homodimerization activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID