BAIT
NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCAS1, FCU, MWS, NALP3, PYPAF1
NLR family, pyrin domain containing 3
GO Process (17)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- apoptotic process [NAS]
- cellular response to lipopolysaccharide [IMP]
- defense response [TAS]
- detection of biotic stimulus [TAS]
- inflammatory response [IMP]
- innate immune response [TAS]
- negative regulation of NF-kappaB import into nucleus [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of acute inflammatory response [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-1 beta secretion [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of interleukin-1 beta secretion [IDA]
- protein oligomerization [TAS]
- signal transduction [NAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
MTCH1
CGI-64, PIG60, PSAP, SLC25A49, RP1-90K10.1
mitochondrial carrier 1
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID