BAIT
BRCA1
RP23-328K2.8
breast cancer 1
GO Process (43)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- DNA replication [IMP]
- G2 DNA damage checkpoint [ISO]
- cellular response to DNA damage stimulus [IMP]
- cellular response to indole-3-methanol [ISO]
- cellular response to tumor necrosis factor [ISO]
- centrosome cycle [IGI]
- centrosome duplication [TAS]
- chordate embryonic development [IMP]
- chromosome segregation [ISO]
- dosage compensation by inactivation of X chromosome [IDA]
- double-strand break repair [ISO]
- double-strand break repair via homologous recombination [IBA, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of fatty acid biosynthetic process [IBA, ISO]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of histone H3-K9 methylation [IMP, ISO]
- negative regulation of histone acetylation [IMP]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell cycle arrest [IBA, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of histone H3-K4 methylation [IMP, ISO]
- positive regulation of histone H3-K9 acetylation [IMP, ISO]
- positive regulation of histone H3-K9 methylation [IMP]
- positive regulation of histone H4-K16 acetylation [IMP, ISO]
- positive regulation of histone H4-K20 methylation [IMP, ISO]
- positive regulation of histone acetylation [IMP, ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation vascular endothelial growth factor production [ISO]
- postreplication repair [ISO]
- protein K6-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein ubiquitination [IBA, ISO]
- regulation of DNA methylation [IMP]
- regulation of cell motility [IBA]
- regulation of cell proliferation [IBA]
- regulation of gene expression by genetic imprinting [IMP]
- response to estrogen [ISO]
- response to ionizing radiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BAD
BBC2, BCL2L8
BCL2-associated agonist of cell death
GO Process (33)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- ADP metabolic process [ISS]
- ATP metabolic process [ISS]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- apoptotic process [IDA, TAS]
- apoptotic signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to nicotine [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- extrinsic apoptotic signaling pathway [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- glucose homeostasis [ISS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [IMP, TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- pore complex assembly [IDA]
- positive regulation of apoptotic process [IDA, IMP, TAS]
- positive regulation of autophagy [TAS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of glucokinase activity [ISS]
- positive regulation of insulin secretion [ISS]
- positive regulation of intrinsic apoptotic signaling pathway [TAS]
- positive regulation of mitochondrial membrane potential [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of type B pancreatic cell development [ISS]
- regulation of mitochondrial membrane permeability [IMP]
- type B pancreatic cell proliferation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID