BAIT
ROCK1
1110055K06Rik, Rock-I
Rho-associated coiled-coil containing protein kinase 1
GO Process (16)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- Rho protein signal transduction [ISO]
- actin cytoskeleton organization [IGI]
- apical constriction [IGI]
- bleb assembly [IMP]
- cytoskeleton organization [ISO]
- leukocyte cell-cell adhesion [ISO]
- leukocyte migration [ISO]
- leukocyte tethering or rolling [ISO]
- membrane to membrane docking [ISO]
- myoblast migration [IMP]
- negative regulation of angiogenesis [ISO]
- negative regulation of neuron apoptotic process [IMP]
- positive regulation of focal adhesion assembly [IMP]
- protein phosphorylation [ISO]
- regulation of actin filament-based process [IGI]
- regulation of keratinocyte differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CDK2
CDKN2, p33(CDK2)
cyclin-dependent kinase 2
GO Process (16)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- DNA replication [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- G2/M transition of mitotic cell cycle [NAS, TAS]
- Ras protein signal transduction [IEP]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- blood coagulation [TAS]
- cellular response to nitric oxide [TAS]
- centrosome duplication [TAS]
- histone phosphorylation [IDA]
- meiotic nuclear division [TAS]
- mitotic G1 DNA damage checkpoint [TAS]
- mitotic cell cycle [TAS]
- positive regulation of cell proliferation [IDA]
- regulation of gene silencing [IDA]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID