BAIT
MBD2
MBD2a
methyl-CpG binding domain protein 2
GO Process (7)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- ATP-dependent chromatin remodeling [ISO]
- cellular protein complex assembly [IMP]
- maternal behavior [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- positive regulation of Wnt signaling pathway [IGI]
- positive regulation of chromatin binding [ISO]
- regulation of cell proliferation [IGI]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- chromatin binding [IDA, ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- nucleosomal DNA binding [ISO]
- protein domain specific binding [ISO]
- siRNA binding [IDA]
- C2H2 zinc finger domain binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- chromatin binding [IDA, ISO]
- mRNA binding [IDA]
- methyl-CpG binding [IDA, ISO]
- nucleosomal DNA binding [ISO]
- protein domain specific binding [ISO]
- siRNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
TPP1
CLN2, LPIC, SCAR7, TPP-1, GIG1
tripeptidyl peptidase I
GO Process (12)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [TAS]
- bone resorption [IMP]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum unfolded protein response [TAS]
- epithelial cell differentiation [IEP]
- lipid metabolic process [TAS]
- lysosome organization [ISS]
- nervous system development [IMP]
- neuromuscular process controlling balance [ISS]
- peptide catabolic process [IMP]
- protein catabolic process [NAS]
- proteolysis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID