BAIT
MYH10
5730504C04Rik, 9330167F11Rik, Fltn, Myhn-2, Myhn2, NMHC II-B, NMHC-B, NMHCII-B, NMMHC II-b, NMMHC-B, NMMHC-IIB, SMemb, mKIAA3005, RP23-396M19.2
myosin, heavy polypeptide 10, non-muscle
GO Process (27)
GO Function (6)
GO Component (21)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin cytoskeleton organization [IGI]
- actin filament-based movement [ISO]
- actomyosin structure organization [ISO]
- adult heart development [IMP]
- axon guidance [IMP]
- axonogenesis [IMP]
- brain development [IMP]
- cardiac myofibril assembly [IMP]
- cell proliferation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- exocytosis [IMP]
- fourth ventricle development [IMP]
- in utero embryonic development [IMP]
- lateral ventricle development [IMP]
- mitotic cytokinesis [IMP, ISO]
- myofibril assembly [IMP]
- neuromuscular process controlling balance [IMP]
- neuron migration [IMP]
- neuron projection development [IMP]
- nuclear migration [IMP]
- plasma membrane repair [IMP]
- regulation of cell shape [IMP]
- retina development in camera-type eye [IMP]
- substrate-dependent cell migration, cell extension [IMP]
- third ventricle development [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [ISO]
- actomyosin [ISO]
- axon [IDA]
- cell cortex [IDA, ISO]
- cleavage furrow [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [IDA]
- extracellular vesicular exosome [ISO]
- growth cone [IDA]
- midbody [ISO]
- mitochondrion [ISO]
- myosin II complex [IDA, ISO]
- myosin II filament [ISO]
- myosin complex [IDA]
- neuromuscular junction [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- spindle [IDA]
- stress fiber [IDA, IMP, ISO]
Mus musculus
PREY
FLNA
ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, XX-FW83128A1.1
filamin A, alpha
GO Process (19)
GO Function (12)
GO Component (10)
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin cytoskeleton reorganization [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cilium assembly [IMP]
- cytoplasmic sequestering of protein [IMP]
- establishment of protein localization [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- protein localization to cell surface [IDA]
- protein stabilization [IMP]
- receptor clustering [IDA]
- spindle assembly involved in mitosis [IDA]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID