BAIT
PRKAA1
AI194361, AI450832, AL024255, AMPKalpha1, C130083N04Rik
protein kinase, AMP-activated, alpha 1 catalytic subunit
GO Process (29)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular response to glucose starvation [IDA]
- cellular response to nutrient levels [IDA]
- cellular response to prostaglandin E stimulus [IGI]
- cold acclimation [ISO]
- fatty acid homeostasis [ISO]
- fatty acid oxidation [IMP]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- histone-serine phosphorylation [IDA]
- lipid biosynthetic process [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of glucose import in response to insulin stimulus [ISO]
- negative regulation of lipid catabolic process [IDA]
- positive regulation of autophagy [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of glycolytic process [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IMP, ISO]
- regulation of circadian rhythm [IMP]
- regulation of energy homeostasis [ISO]
- regulation of vesicle-mediated transport [ISO]
- response to UV [IMP]
- response to activity [ISO]
- response to caffeine [ISO]
- response to camptothecin [IMP]
- response to gamma radiation [IMP]
- response to hydrogen peroxide [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
FLNA
ABP-280, ABPX, CSBS, CVD1, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, XX-FW83128A1.1
filamin A, alpha
GO Process (19)
GO Function (12)
GO Component (10)
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin cytoskeleton reorganization [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cilium assembly [IMP]
- cytoplasmic sequestering of protein [IMP]
- establishment of protein localization [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- protein localization to cell surface [IDA]
- protein stabilization [IMP]
- receptor clustering [IDA]
- spindle assembly involved in mitosis [IDA]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID