BAIT
TGFBR1
ALK5, AU017191, Alk-5, TbetaR-I, TbetaRI, RP23-457P12.1
transforming growth factor, beta receptor I
GO Process (54)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- angiogenesis [IMP]
- anterior/posterior pattern specification [IGI]
- artery morphogenesis [IMP]
- blastocyst development [IDA]
- cell motility [ISO]
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- collagen fibril organization [IMP]
- embryo development [IMP]
- embryonic cranial skeleton morphogenesis [IMP]
- endothelial cell migration [IMP]
- epithelial to mesenchymal transition [ISO]
- germ cell migration [IMP]
- heart development [IMP]
- in utero embryonic development [IMP]
- kidney development [IGI]
- lens development in camera-type eye [IMP]
- male gonad development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of endothelial cell differentiation [ISO]
- negative regulation of endothelial cell proliferation [IGI]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- neuron fate commitment [IMP]
- palate development [IGI, IMP]
- parathyroid gland development [IMP]
- pathway-restricted SMAD protein phosphorylation [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- pharyngeal system development [IMP]
- positive regulation of SMAD protein import into nucleus [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of filopodium assembly [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- post-embryonic development [IMP]
- protein autophosphorylation [ISO]
- protein phosphorylation [IGI, ISO]
- regulation of gene expression [IMP]
- regulation of protein binding [IMP]
- regulation of protein ubiquitination [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to cholesterol [IDA, ISO]
- response to estrogen [ISO]
- signal transduction [ISO]
- skeletal system development [IGI]
- skeletal system morphogenesis [IGI]
- thymus development [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, IMP, ISO]
- transmembrane receptor protein serine/threonine kinase signaling pathway [IGI]
Gene Ontology Molecular Function- ATP binding [ISO]
- I-SMAD binding [ISO]
- SMAD binding [IDA, ISO]
- growth factor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [IDA, IGI, ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- I-SMAD binding [ISO]
- SMAD binding [IDA, ISO]
- growth factor binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- transforming growth factor beta binding [IPI, ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transforming growth factor beta-activated receptor activity [IDA, IGI, ISO]
- type II transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA8
HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
heat shock 70kDa protein 8
GO Process (14)
GO Function (11)
GO Component (13)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- RNA metabolic process [TAS]
- axon guidance [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of fibril organization [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotransmitter secretion [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- protein folding [NAS]
- protein refolding [IDA]
- response to unfolded protein [NAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [NAS]
- G-protein coupled receptor binding [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled [NAS]
- G-protein coupled receptor binding [IPI]
- MHC class II protein complex binding [IDA]
- enzyme binding [IPI]
- heat shock protein binding [IPI]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- unfolded protein binding [IDA]
Gene Ontology Cellular Component
- Prp19 complex [IDA]
- blood microparticle [IDA]
- clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [TAS]
- cytosol [IDA, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- intracellular [NAS]
- membrane [IDA]
- nucleus [IDA]
- plasma membrane [TAS]
- ribonucleoprotein complex [IDA]
- ubiquitin ligase complex [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID