BAIT
ATP7A
MNK, RP23-186F4.3
ATPase, Cu++ transporting, alpha polypeptide
GO Process (47)
GO Function (6)
GO Component (16)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ATP metabolic process [IMP]
- T-helper cell differentiation [IMP]
- blood vessel development [IMP]
- blood vessel remodeling [IMP]
- cartilage development [IMP]
- catecholamine metabolic process [IMP]
- cellular copper ion homeostasis [IGI, IMP, ISO]
- central nervous system neuron development [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- collagen fibril organization [IMP]
- copper ion export [IDA, IMP]
- copper ion import [IMP]
- copper ion transport [IDA, IMP, ISO]
- dendrite morphogenesis [IMP]
- detoxification of copper ion [IMP]
- dopamine metabolic process [IMP]
- elastic fiber assembly [IMP]
- elastin biosynthetic process [IMP]
- epinephrine metabolic process [IMP]
- extracellular matrix organization [IMP]
- hair follicle morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- locomotory behavior [IMP]
- lung alveolus development [IMP]
- mitochondrion organization [IMP]
- negative regulation of metalloenzyme activity [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neuron projection morphogenesis [IMP]
- norepinephrine biosynthetic process [IMP]
- norepinephrine metabolic process [IMP]
- peptidyl-lysine modification [IMP]
- pigmentation [IMP]
- plasma membrane copper ion transport [ISO]
- positive regulation of catalytic activity [IDA, IMP]
- positive regulation of metalloenzyme activity [IMP]
- positive regulation of oxidoreductase activity [ISO]
- pyramidal neuron development [IMP]
- regulation of gene expression [IMP]
- regulation of oxidative phosphorylation [IMP]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IMP]
- response to copper ion [ISO]
- serotonin metabolic process [IMP]
- skin development [IMP]
- tryptophan metabolic process [IMP]
- tyrosine metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell [IGI]
- cytoplasmic vesicle [IDA]
- endoplasmic reticulum [ISO]
- integral component of membrane [ISO]
- late endosome [ISO]
- membrane [IDA, ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- secretory granule [ISO]
- trans-Golgi network [IDA, ISO]
- trans-Golgi network transport vesicle [ISO]
Mus musculus
PREY
MEN1
MEAI, SCG2
multiple endocrine neoplasia I
GO Process (24)
GO Function (9)
GO Component (9)
Gene Ontology Biological Process
- DNA repair [NAS]
- MAPK cascade [IDA]
- cellular response to DNA damage stimulus [IDA]
- gene expression [TAS]
- histone lysine methylation [IDA]
- negative regulation of JNK cascade [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of telomerase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- osteoblast development [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP]
- response to UV [IDA]
- response to gamma radiation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID