BAIT
HSF1
AA960185, Hsf1alpha, Hsf1beta
heat shock factor 1
GO Process (17)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- cellular response to heat [ISO]
- defense response [ISO]
- embryonic placenta development [IMP]
- embryonic process involved in female pregnancy [IMP]
- female meiotic division [IMP]
- in utero embryonic development [IMP]
- negative regulation of cell proliferation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [IDA]
- regulation of spindle checkpoint [IMP]
- response to heat [IMP]
- response to lipopolysaccharide [IMP]
- spermatogenesis [IGI]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [ISO]
- chromatin binding [IDA]
- sequence-specific DNA binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [ISO]
- chromatin binding [IDA]
- sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
NDUFV2
CI-24k
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID