BAIT
HDAC6
Hd6, Hdac5, Sfc6, mHDA2, RP23-198C2.1
histone deacetylase 6
GO Process (34)
GO Function (15)
GO Component (19)
Gene Ontology Biological Process
- Hsp90 deacetylation [IMP, ISO]
- aggresome assembly [IGI, ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to misfolded protein [IMP]
- cellular response to topologically incorrect protein [ISO]
- histone deacetylation [IDA, ISO]
- intracellular protein transport [ISO]
- lysosome localization [ISO]
- macroautophagy [ISO]
- misfolded or incompletely synthesized protein catabolic process [ISO]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of protein complex disassembly [ISO]
- negative regulation of proteolysis [ISO]
- peptidyl-lysine deacetylation [ISO]
- polyubiquitinated misfolded protein transport [ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of hydrogen peroxide-mediated programmed cell death [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of signal transduction [ISO]
- protein complex disassembly [IGI]
- protein deacetylation [IDA, ISO]
- protein polyubiquitination [IDA]
- regulation of establishment of protein localization [IMP]
- regulation of fat cell differentiation [IMP]
- regulation of gene expression, epigenetic [ISO]
- regulation of receptor activity [ISO]
- response to growth factor [ISO]
- response to misfolded protein [ISO]
- response to organic substance [ISO]
- response to toxic substance [ISO]
- tubulin deacetylation [IDA, IMP, ISO]
- ubiquitin-dependent protein catabolic process [IGI, IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IMP]
Gene Ontology Molecular Function- Hsp90 protein binding [ISO]
- alpha-tubulin binding [ISO]
- beta-catenin binding [ISO]
- beta-tubulin binding [IDA]
- core promoter binding [ISO]
- dynein complex binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- microtubule binding [IDA, ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [ISO]
- Hsp90 protein binding [ISO]
- alpha-tubulin binding [ISO]
- beta-catenin binding [ISO]
- beta-tubulin binding [IDA]
- core promoter binding [ISO]
- dynein complex binding [ISO]
- histone deacetylase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- microtubule binding [IDA, ISO]
- polyubiquitin binding [ISO]
- protein binding [IPI]
- tau protein binding [ISO]
- tubulin deacetylase activity [IDA, ISO]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- aggresome [ISO]
- axon [IDA, ISO]
- caveola [ISO]
- cell leading edge [ISO]
- centrosome [ISO]
- cytoplasm [IDA]
- cytoplasmic microtubule [IDA]
- cytosol [IDA]
- dendrite [IDA]
- dynein complex [ISO]
- histone deacetylase complex [ISO]
- inclusion body [ISO]
- microtubule [ISO]
- microtubule associated complex [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, TAS]
- perikaryon [IDA]
- perinuclear region of cytoplasm [ISO]
- protein complex [IPI]
Mus musculus
PREY
PDHA1
PDHA, PDHAD, PDHCE1A, PHE1A, RP11-723P2.1
pyruvate dehydrogenase (lipoamide) alpha 1
GO Process (6)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID