BAIT
RAB5C
AI326010, Rabl, RP23-390D17.8
RAB5C, member RAS oncogene family
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SLC9A1
APNH, NHE-1, NHE1, PPP1R143, RP4-633N17.1
solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
GO Process (32)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell migration [TAS]
- cellular response to acidic pH [IDA, ISS]
- cellular response to epinephrine stimulus [IMP]
- cellular response to mechanical stimulus [TAS]
- cellular sodium ion homeostasis [IDA]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [TAS]
- hyaluronan metabolic process [TAS]
- hydrogen ion transmembrane transport [IDA]
- ion transport [TAS]
- maintenance of cell polarity [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of calcium:sodium antiporter activity [IMP]
- positive regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein oligomerization [ISS]
- regulation of cardiac muscle cell membrane potential [TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of focal adhesion assembly [TAS]
- regulation of intracellular pH [IDA]
- regulation of pH [IDA, TAS]
- regulation of stress fiber assembly [TAS]
- regulation of the force of heart contraction by cardiac conduction [IMP]
- response to acidic pH [IDA]
- response to muscle stretch [IMP]
- small molecule metabolic process [TAS]
- sodium ion export [ISS]
- sodium ion import across plasma membrane [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- calcium-dependent protein binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [TAS]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein complex scaffold [TAS]
- protein phosphatase 2B binding [IDA, IPI]
- sodium:proton antiporter activity [IDA, ISS]
- sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [TAS]
- solute:proton antiporter activity [TAS]
- calcium-dependent protein binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [TAS]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein complex scaffold [TAS]
- protein phosphatase 2B binding [IDA, IPI]
- sodium:proton antiporter activity [IDA, ISS]
- sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [TAS]
- solute:proton antiporter activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID