BAIT
SMAD3
AU022421, Madh3, RP23-63E8.1
SMAD family member 3
GO Process (73)
GO Function (31)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [IGI]
- T cell activation [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- activin receptor signaling pathway [ISO]
- cell cycle arrest [ISO]
- cell-cell junction organization [ISO]
- developmental growth [IGI]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic foregut morphogenesis [IGI]
- embryonic pattern specification [IGI]
- endoderm development [IGI]
- evasion or tolerance of host defenses by virus [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- gastrulation [IGI]
- heart looping [IGI]
- immune response [ISO]
- immune system development [IGI]
- in utero embryonic development [IGI]
- intracellular signal transduction [ISO]
- lens fiber cell differentiation [IMP]
- liver development [IGI]
- mesoderm formation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of wound healing [IMP]
- nodal signaling pathway [ISO]
- osteoblast development [IGI]
- osteoblast differentiation [IMP]
- paraxial mesoderm morphogenesis [IMP]
- pericardium development [IGI]
- positive regulation of alkaline phosphatase activity [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta3 production [ISO]
- protein stabilization [ISO]
- regulation of binding [IDA]
- regulation of epithelial cell proliferation [IMP]
- regulation of immune response [IMP]
- regulation of striated muscle tissue development [IDA]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [IDA, ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to hypoxia [ISO]
- signal transduction involved in regulation of gene expression [ISO]
- skeletal system development [IGI]
- somitogenesis [IMP]
- thyroid gland development [IGI]
- transcription from RNA polymerase II promoter [ISO, TAS]
- transdifferentiation [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- transport [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
- DNA binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
UBL4A
DX254E, DXS254E, G6PD, GDX, GET5, MDY2, TMA24, UBL4, XX-FW89031B12.1
ubiquitin-like 4A
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID