BAIT
APC
AI047805, AU020952, AW124434, CC1, Min, mAPC
adenomatosis polyposis coli
GO Process (59)
GO Function (9)
GO Component (30)
Gene Ontology Biological Process
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA, IMP]
- anterior/posterior pattern specification [IMP]
- axis specification [IMP]
- axonogenesis [IGI, IMP]
- canonical Wnt signaling pathway [IMP]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IGI]
- cell cycle arrest [ISO]
- cell migration [IMP, ISO]
- cellular response to DNA damage stimulus [ISO]
- chromosome organization [IGI, IMP]
- cytoplasmic microtubule organization [IGI]
- dorsal/ventral pattern formation [IMP]
- establishment or maintenance of cell polarity [ISO]
- hair follicle development [IMP]
- kidney development [IMP]
- metaphase/anaphase transition of mitotic cell cycle [IGI, IMP]
- mitotic cytokinesis [IMP, ISO]
- mitotic spindle assembly checkpoint [ISO]
- muscle cell cellular homeostasis [IGI]
- negative regulation of MAPK cascade [IGI, IMP]
- negative regulation of Wnt signaling pathway [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- negative regulation of epithelial cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- negative regulation of microtubule depolymerization [IMP, ISO]
- negative regulation of odontogenesis [IMP]
- neuron projection development [ISO]
- pattern specification process [IMP]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell division [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of epithelial cell differentiation [IGI]
- positive regulation of microtubule polymerization [IMP]
- positive regulation of protein catabolic process [IMP, ISO]
- positive regulation of pseudopodium assembly [ISO]
- protein complex assembly [ISO]
- proximal/distal pattern formation [IMP]
- regulation of attachment of spindle microtubules to kinetochore [IMP, ISO]
- regulation of cell cycle [IMP]
- regulation of cell differentiation [IGI]
- regulation of cell migration [IGI, IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of glutamate metabolic process [ISO]
- regulation of microtubule-based process [ISO]
- regulation of nitrogen compound metabolic process [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- retina development in camera-type eye [IMP]
- skin development [IMP]
- somatic stem cell maintenance [IGI, IMP]
- stem cell maintenance [IMP]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- axon [IDA]
- axonal growth cone [IDA, ISO]
- beta-catenin destruction complex [ISO]
- cell [IGI]
- cell body fiber [ISO]
- cell cortex [ISO]
- cell projection [IDA]
- cell projection membrane [IDA]
- cell-cell adherens junction [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic microtubule [IDA]
- dendrite [ISO]
- growth cone [IDA, ISO]
- kinetochore [ISO]
- lamellipodium [ISO]
- lateral plasma membrane [ISO]
- microtubule [ISO]
- microtubule plus-end [IDA]
- neuron projection [ISO]
- neuron projection terminus [ISO]
- neuronal cell body [ISO]
- nuclear membrane [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ruffle membrane [ISO]
- synapse [ISO]
- tight junction [ISO]
Mus musculus
PREY
AXIN1
AXIN, PPP1R49, LA16c-314G4.3
axin 1
GO Process (33)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [IDA]
- axial mesoderm formation [IBA]
- canonical Wnt signaling pathway [IC]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [IDA]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IBA]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IBA]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IBA]
- forebrain anterior/posterior pattern specification [IBA]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IBA]
- negative regulation of fat cell differentiation [IBA]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [ISS]
- positive regulation of peptidyl-serine phosphorylation [NAS]
- positive regulation of peptidyl-threonine phosphorylation [NAS]
- positive regulation of protein catabolic process [IC, IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of protein ubiquitination [NAS]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of ubiquitin-protein transferase activity [IMP]
- regulation of catenin import into nucleus [IBA]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [IPI]
- SMAD binding [IPI]
- armadillo repeat domain binding [IBA, ISS]
- beta-catenin binding [IDA]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein complex scaffold [IDA, IMP]
- protein homodimerization activity [ISS]
- protein kinase binding [IBA, ISS]
- signal transducer activity [IDA]
- ubiquitin protein ligase binding [IPI]
- GTPase activator activity [IBA]
- I-SMAD binding [IPI]
- SMAD binding [IPI]
- armadillo repeat domain binding [IBA, ISS]
- beta-catenin binding [IDA]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein complex scaffold [IDA, IMP]
- protein homodimerization activity [ISS]
- protein kinase binding [IBA, ISS]
- signal transducer activity [IDA]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA]
- cell cortex [IBA]
- cell periphery [IDA]
- cytoplasm [IDA]
- cytoplasmic membrane-bounded vesicle [IBA]
- cytoplasmic microtubule [IBA]
- cytoplasmic vesicle [ISS]
- cytosol [TAS]
- lateral plasma membrane [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [IBA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID