BAIT
PTPN2
AI325124, Ptpt, TC-PTP
protein tyrosine phosphatase, non-receptor type 2
GO Process (31)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- T cell differentiation [IMP]
- erythrocyte differentiation [IMP]
- glucose homeostasis [IMP]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of chemotaxis [IMP]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of interferon-gamma-mediated signaling pathway [IMP]
- negative regulation of interleukin-2-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-4-mediated signaling pathway [IMP, ISO]
- negative regulation of interleukin-6-mediated signaling pathway [IMP, ISO]
- negative regulation of lipid storage [IMP]
- negative regulation of macrophage colony-stimulating factor signaling pathway [IMP]
- negative regulation of macrophage differentiation [IMP]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [IMP]
- negative regulation of positive thymic T cell selection [IMP]
- negative regulation of prolactin signaling pathway [IMP]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- negative regulation of type I interferon-mediated signaling pathway [IMP, ISO]
- negative regulation of tyrosine phosphorylation of Stat3 protein [ISO]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- negative regulation of tyrosine phosphorylation of Stat6 protein [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- positive regulation of gluconeogenesis [IMP]
- protein dephosphorylation [IMP]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MVP
LRP, VAULT1
major vault protein
GO Process (4)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID