BAIT
MARK2
EMK-1, Emk, Par-1, Par-1b
MAP/microtubule affinity-regulating kinase 2
GO Process (9)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- establishment of cell polarity [ISO]
- establishment or maintenance of epithelial cell apical/basal polarity [ISO]
- intracellular signal transduction [ISO]
- neuron migration [ISO]
- positive regulation of neuron projection development [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of axonogenesis [ISO]
- regulation of cytoskeleton organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RNF41
FLRF, NRDP1, SBBI03
ring finger protein 41, E3 ubiquitin protein ligase
GO Process (10)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [IDA]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IDA]
- positive regulation of reactive oxygen species metabolic process [IMP]
- proteasomal protein catabolic process [IDA]
- protein autoubiquitination [IDA]
- protein polyubiquitination [IDA]
- regulation of MAPK cascade [IDA]
- regulation of protein kinase B signaling [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID