BAIT
TPM1
AA986836, AI854628, TM2, Tm3, Tmpa, Tpm-1, alpha-TM
tropomyosin 1, alpha
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- actin filament capping [ISO]
- cardiac muscle contraction [IMP, ISO]
- embryo development [IMP]
- in utero embryonic development [IMP]
- muscle filament sliding [ISO]
- negative regulation of cell migration [ISO]
- positive regulation of ATPase activity [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of heart rate by epinephrine [IMP]
- positive regulation of stress fiber assembly [ISO]
- regulation of ATPase activity [ISO]
- ruffle organization [ISO]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CORO1B
CORONIN-2
coronin, actin binding protein, 1B
GO Process (10)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- actin cytoskeleton organization [IBA]
- actin filament branching [IDA]
- actin filament bundle assembly [IDA]
- cell migration [IDA]
- endothelial cell chemotaxis [IDA]
- negative regulation of Arp2/3 complex-mediated actin nucleation [IDA]
- positive regulation of lamellipodium morphogenesis [IDA]
- protein localization to cell leading edge [IDA]
- ruffle organization [IDA]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID