BAIT
CSK
AW212630
c-src tyrosine kinase
GO Process (25)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- adherens junction organization [IBA]
- cell differentiation [IBA]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [ISO]
- central nervous system development [IBA]
- innate immune response [IBA]
- intracellular signal transduction [TAS]
- morphogenesis of an epithelium [IBA]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of Golgi to plasma membrane protein transport [ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of kinase activity [ISO]
- negative regulation of low-density lipoprotein particle clearance [ISO]
- negative regulation of phagocytosis [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of MAP kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO, TAS]
- regulation of Fc receptor mediated stimulatory signaling pathway [IBA, ISO]
- regulation of T cell activation [TAS]
- regulation of cytokine production [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ITIH6
ITIH5L, UNQ6369, dJ14O9.1, RP1-159A15.1
inter-alpha-trypsin inhibitor heavy chain family, member 6
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances.
The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have generated a library of HeLa cell lines expressing 1,125 GFP-tagged proteins ... [more]
Cell Oct. 22, 2015; 163(3);712-23 [Pubmed: 26496610]
Throughput
- High Throughput
Additional Notes
- interaction detected by quantitative BAC-GFP interactomics (QUBIC)
Curated By
- BioGRID