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Y75_p2174
fused DNA-binding transcriptional dual regulator and O6-methylguanine-DNA methyltransferase
GO Process (0)
GO Function (0)
GO Component (0)
Escherichia coli (K12/W3110)
PREY

YCEP

Y75_p1030
hypothetical protein
GO Process (0)
GO Function (0)
GO Component (0)
Escherichia coli (K12/W3110)

Positive Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.

Publication

Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.

Kumar A, Beloglazova N, Bundalovic-Torma C, Phanse S, Deineko V, Gagarinova A, Musso G, Vlasblom J, Lemak S, Hooshyar M, Minic Z, Wagih O, Mosca R, Aloy P, Golshani A, Parkinson J, Emili A, Yakunin AF, Babu M

As antibiotic resistance is increasingly becoming a public health concern, an improved understanding of the bacterial DNA damage response (DDR), which is commonly targeted by antibiotics, could be of tremendous therapeutic value. Although the genetic components of the bacterial DDR have been studied extensively in isolation, how the underlying biological pathways interact functionally remains unclear. Here, we address this by ... [more]

Cell Rep Jan. 07, 2016; 0(0); [Pubmed: 26774489]

Quantitative Score

  • 3.16 [Confidence Score]

Throughput

  • High Throughput

Additional Notes

  • Genetic interactions were considered significant if they had an S-score >= 2.0 for positive interactions (alleviating interactions) and S-score <= -2.0 for negative interactions (aggravating interactions).
  • Rich Media
  • colony size phenotype (OMP:0000179)

Curated By

  • BioGRID