Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Prudden J, Perry JJ, Nie M, Vashisht AA, Arvai AS, Hitomi C, Guenther G, Wohlschlegel JA, Tainer JA, Boddy MN

Global sumoylation, SUMO chain formation, and genome stabilization are all outputs generated by a limited repertoire of enzymes. Mechanisms driving selectivity for each of these processes are largely uncharacterized. Here, through crystallographic analyses we show that the SUMO E2 Ubc9 forms a noncovalent complex with a SUMO-like domain of Rad60 (SLD2). Ubc9:SLD2 and Ubc9:SUMO noncovalent complexes are structurally analogous, suggesting ... [more]

Mol. Cell. Biol. Jun. 01, 2011; 31(11);2299-310 [Pubmed: 21444718]


  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)

Additional Notes

  • Interactor A: null
  • Interactor B: SUMOD81R

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.


Curated By

  • BioGRID