BRR2
Gene Ontology Biological Process
Gene Ontology Molecular Function
SEM1
Gene Ontology Biological Process
- SAGA complex localization to transcription regulatory region [IMP]
- exocytosis [IGI, IPI]
- filamentous growth [IMP]
- histone deubiquitination [IMP]
- mRNA export from nucleus [IGI, IMP, IPI]
- maintenance of DNA trinucleotide repeats [IMP]
- proteasome assembly [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA, IMP]
- regulation of cell cycle [IMP]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.
RNA helicases are essential for virtually all cellular processes, however, their regulation is poorly understood. The activities of eight RNA helicases are required for pre-mRNA splicing. Amongst these, Brr2p is unusual in having two helicase modules, of which only the amino-terminal helicase domain appears to be catalytically active. Using genetic and biochemical approaches, we investigated interaction of the carboxy-terminal helicase ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Genetic Interaction Mapping screen
- Table S4
- brr2L1930P, brr2L1951P alleles used
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
BRR2 SEM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1776 | BioGRID | 1977861 |
Curated By
- BioGRID