BAIT
CYCS
CYC, HCS, THC4
cytochrome c, somatic
GO Process (11)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [TAS]
- apoptotic DNA fragmentation [IMP]
- apoptotic process [TAS]
- cellular metabolic process [TAS]
- cellular respiration [TAS]
- dephosphorylation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitochondrial electron transport, cytochrome c to oxygen [IBA]
- mitochondrial electron transport, ubiquinol to cytochrome c [IBA]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CASP9
APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, RP11-265F14.3
caspase 9, apoptosis-related cysteine peptidase
GO Process (17)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [TAS]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- platelet formation [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- regulation of response to DNA damage stimulus [IMP]
- signal transduction in response to DNA damage [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apoptosome [IDA]
- cytosol [IDA, TAS]
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Signal transduction pathways in the cell require protein-protein interactions (PPIs) to respond to environmental cues. Diverse experimental techniques for detecting PPIs have been developed. However, the huge amount of PPI data accumulated from various sources poses a challenge with respect to data reliability. Herein, we collected ∼ 700 primary antibodies and employed a highly sensitive and specific technique, an in ... [more]
J. Proteome Res. Dec. 05, 2014; 13(12);5339-46 [Pubmed: 25241761]
Throughput
- High Throughput
Additional Notes
- in situ PLA
Curated By
- BioGRID